An evaluation of the retinal nerve fiber layer thickness by scanning laser polarimetry in individuals with dementia of the Alzheimer type
- 1 April 2001
- journal article
- research article
- Published by Wiley in Acta Ophthalmologica Scandinavica
- Vol. 79 (2) , 187-191
- https://doi.org/10.1034/j.1600-0420.2001.079002187.x
Abstract
Purpose: To determine, using scanning laser polarimetry, whether or not the retinal nerve fiber layer (RNFL) is altered in dementia of the Alzheimer type (DAT).Methods: Thirty individuals with mild to moderate DAT and 30 healthy age‐matched controls participated in the study. Fundus images were acquired with a Nerve Fiber Analyzer. RNFL thickness measurements were obtained under an ellipse located 1.75 disc diameter from the optic nerve head (ONH) center.Results: No differences in RNFL thickness were observed between DAT and healthy subjects. The regional distribution of RNFL thickness was similar between the two test groups, with the RNFL being thickest in the superior and inferior retinal segments relative to the nasal and temporal regions.Conclusions: Our data indicate that the RNFL is not altered in DAT, at least in the earlier stages of the disease.Keywords
This publication has 29 references indexed in Scilit:
- Scanning laser polarimetry of the retinal nerve fibre layer in primary open angle and capsular glaucomaBritish Journal of Ophthalmology, 1997
- Visual Field Defects in Alzheimer???s Disease Patients May Reflect Differential Pathology in the Primary Visual CortexOptometry and Vision Science, 1996
- Retinal pathology in Alzheimer's disease. II. Regional neuron loss and glial changes in GCLNeurobiology of Aging, 1996
- Myelinated axon number in the optic nerve is unaffected by Alzheimer's disease.British Journal of Ophthalmology, 1995
- Vision in Alzheimer's DiseaseThe Gerontologist, 1995
- Visual Dysfunction Predicts Cognitive Deficits in Alzheimer??s DiseaseOptometry and Vision Science, 1995
- Retinal ganglion cells in Alzheimer's disease and agingAnnals of Neurology, 1993
- Retinal ganglion cell degeneration in Alzheimer's diseaseBrain Research, 1989
- Optic-Nerve Degeneration in Alzheimer's DiseaseNew England Journal of Medicine, 1986
- Clinical diagnosis of Alzheimer's diseaseNeurology, 1984