Influence of Preparation and Immunosuppression Upon Longevity of Grafted Aortic Valves
- 1 December 1970
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Surgery
- Vol. 101 (6) , 658-662
- https://doi.org/10.1001/archsurg.1970.01340300014004
Abstract
Aortic valves were transplanted from sheep and pigs into the descending thoracic aortas of nine groups of dogs. The valves were fresh, freeze-dried, or treated with propiolactone. Half the groups received azathioprine. The following conditions led to the best results: (1) transplantation of a minimum of aortic wall with the valve; (2) good initial alignment and movement of the cusps; (3) administration of azathioprine for eight weeks; and (4) support of the graft by a Dacron tube, preventing rupture and separating the graft from ingrowing host tissue.Keywords
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