Model studies with enzyme inhibitors. Addition of nucleophiles to conjugated allenic 3-oxo-5,10-secosteroids

1 January 1979

journal article
research article
Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications

No. 18,p. 795-796
https://doi.org/10.1039/c39790000795

Abstract

The Michael addition of nucleophiles to the enzyme inhibitor 5,10-seco-oestra-4,5-diene-3,10,17-trione (2) gives 5,10-seco-oestr-5-ene derivatives (3) or A-homo-B-noroestr-4-ene derivatives (4) depending on the nucleophile.

Keywords

ENZYME