Once Daily Dosage Beta‐Blockade: Antihypertensive Efficacy of Slow Release Oxprenolol as Related to Renin and Age

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Abstract
Summary: Once daily dosage beta‐blockade: Antihypertensive efficacy of slow release oxprenolol as related to renin and age.A single daily dose antihypertensive therapy with a new slow‐release (SR) form of the beta‐adrenoceptor blocking agent oxprenolol was as effective as a standard tid beta‐blocker regimen in maintaining therapeutic effects over 24 hours. The good overall response rate (target ≤ 95 mmHg diastolic) of 67% was achieved in eight of the 11 high renin patients and 16 out of the 20 normal renin ones; the five low renin patients, who were also older, proved to be non‐responsive. In terms of age, 83% of the patients aged under 40 years showed a reduction in diastolic pressure to ≤ 95 mmHg, this percentage being significantly better than the 50% response rate in the 40–56‐year‐olds.In nine of the 12 beta‐blocker non‐responders the diastolic blood pressure was reduced to ≤ 95 mmHg by adding a diuretic, and in four of the nine, all of them low renin patients, this effect persisted in response to diuretics alone. Oxprenolol SR suppresses renin acutely (59%) and chronically (62%), and it blunts the renin stimulatory effects of diuretics.