Histochemical detection of the enzyme deficiency in blood films in Wolman's disease
Open Access
- 1 October 1971
- journal article
- research article
- Published by BMJ in Journal of Clinical Pathology
- Vol. 24 (7) , 617-620
- https://doi.org/10.1136/jcp.24.7.617
Abstract
The clinical diagnosis of Wolman's disease (acid esterase deficiency) can be confirmed by a histochemical staining method using blood films. Acid esterase activity is found normally in lymphocytes, but in Wolman's disease only a very low level of activity can be detected. An intermediate level of activity was demonstrated in heterozygotes. The method may also be applicable in the prenatal detection of the disease.Keywords
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