Stereoselective Synthesis of the C13-C19 Fragment of the Cytotoxic Marine Products Calyculins; Part 11
- 1 January 1991
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1991 (04) , 283-284
- https://doi.org/10.1055/s-1991-20709
Abstract
The stereoselective synthesis of the C13-C19 fragment 2b [(7S)-hexahydro-5-hydroxy-7-methoxy-3,3-dimethyl-2-oxofuro-[3,2-b]pyran] of the cytotoxic marine products calyculins (1 or their antipodes) from potassium (R)-2,3-O-isopropylideneglycerate (3) has been completed utilizing stereoselective hydrogenation of the 5-substituted tetronic acid derivative 8 [(5S)-5-(tert-butyldimethylsiloxymethyl)-4-hydroxy-3-methyl-2(5H)-furanone] and the stereoselective allylation of the furanose aldehyde 12 [(2S,3R)-3-benzyloxy-5-methoxy-4,4-dimethyltetrahydrofuran-2-carbaldehyde].Keywords
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