The Use of Gas Chromatography/Negative Ion Chemical Ionization Mass Spectrometry for the Determination of Lorazepam in Whole Blood
- 1 March 1989
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Analytical Toxicology
- Vol. 13 (2) , 69-72
- https://doi.org/10.1093/jat/13.2.69
Abstract
The determination of Iorazepam in blood by gas chromatography/mass spectrometry with selected ion monitoring (GC/MS/SIM) in the negative chemical ionization mode (NICI) was investigated. The method involves a single extraction with Amberlite® XAD-2 resin and the use of [2H6]triazolam as an internal standard. The limit of detection is 0.5 ng/mL and standard curves are linear from 6.25 to 250 ng/mL. The applicability of the method to forensic toxicology is reported.This publication has 3 references indexed in Scilit:
- High-performance liquid chromatographic determination of lorazepam in monkey plasmaJournal of Chromatography B: Biomedical Sciences and Applications, 1981
- Analysis of lorazepam and its glucoronide metabolite by electron-capture gas—liquid chromatographyJournal of Chromatography B: Biomedical Sciences and Applications, 1978
- CLINICAL PROFILE OF LORAZEPAM - NEW BENZODIAZEPINE TRANQUILIZER1978