A Phase II Trial of Vindesine in Hepatocellular Cancer
- 1 January 1995
- journal article
- clinical trial
- Published by S. Karger AG in Oncology
- Vol. 52 (1) , 86-87
- https://doi.org/10.1159/000227434
Abstract
Sixteen patients with histologically confirmed inoperable hepatocellular carcinoma were treated with vindesine 3 mg/m2 i.v. weekly. Anemia, leukopenia and neuritis were documented but no severe or life-threatening toxicity was seen. There were no objective responses among the 14 evaluable patients. Eight had a no change status (median duration of 16 weeks, range 6-33), while the remaining 6 had progressive disease as their best evaluation. The median survival time was 20 weeks. Vindesine does not have a therapeutic effect in patients with advanced hepatocellular carcinoma.Keywords
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