Prevalence and degree of expression of the carbapenemase gene (cfiA) among clinical isolates of Bacteroides fragilis in Nottingham, UK
Open Access
- 1 February 1999
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 43 (2) , 273-276
- https://doi.org/10.1093/jac/43.2.273
Abstract
The carbapenemase gene (cfiA) was detected in 12 (6.9%) out of 175 clinical isolates of Bacteroides fragilis from Nottingham, three times the frequency reported from France. Only one gene copy was present in all cases. Eleven (6.3%) of the cfiA-positive isolates were susceptible to imipenem or meropenem (MIC < 8 mg/L); strains of this type have the potential to convert to high-level resistance. One isolate (0.6%) displayed resistance to both carbapenem antibiotics and was associated with specific carbapenemase activity six times that of the sensitive isolates.Keywords
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