Novel and potent cyclic cyanamide-based cathepsin K inhibitors
- 1 April 2005
- journal article
- research article
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 15 (7) , 1815-1819
- https://doi.org/10.1016/j.bmcl.2005.02.033
Abstract
No abstract availableKeywords
This publication has 13 references indexed in Scilit:
- Exploration of the P2–P3 SAR of aldehyde cathepsin K inhibitorsBioorganic & Medicinal Chemistry Letters, 2004
- Cathepsin K Inhibitors: Their Potential as Anti-Osteoporosis AgentsProgress in Medicinal Chemistry, 2004
- Exploration of the P1 SAR of aldehyde cathepsin K inhibitorsBioorganic & Medicinal Chemistry Letters, 2003
- Peptidic 1-cyanopyrrolidines: synthesis and SAR of a series of potent, selective cathepsin inhibitorsBioorganic & Medicinal Chemistry, 2002
- Collagenase Activity of Cathepsin K Depends on Complex Formation with Chondroitin SulfateJournal of Biological Chemistry, 2002
- Potent and Selective Inhibition of Human Cathepsin K Leads to Inhibition of Bone Resorption In Vivo in a Nonhuman PrimateJournal of Bone and Mineral Research, 2001
- Novel, Nonpeptidic Cyanamides as Potent and Reversible Inhibitors of Human Cathepsins K and LJournal of Medicinal Chemistry, 2000
- Pycnodysostosis, a Lysosomal Disease Caused by Cathepsin K DeficiencyScience, 1996
- Homochiral Proline N-Oxides as Conformational Constraints in Peptide Like MoleculesSynlett, 1995
- Phosphodiesterase Type IV Inhibition. Structure-Activity Relationships of 1,3-Disubstituted PyrrolidinesJournal of Medicinal Chemistry, 1995