A 46-year-old white male with dermal and subcutaneous melanoma metastases of the left leg and contralateral inguinal lymph node involvement was treated with intratumoral BCG. Over 9 months, 84 dermal and subcutaneous lesions were inoculated with BCG. It produced an inflammatory response and regression of all treated dermal and most treated subcutaneous metastases. All untreated dermal lesions also regressed. Histologically, melanin-laden macrophages and a chronic granulomatous reaction were noted. While clinical examination revealed no regression of uninoculated subcutaneous metastases, histologic study showed the tissue surrounding the untreated subcutaneous metastases to be heavily laden with lymphocytes which in areas infiltrated the laminated fibrocollagenous capsule surrounding these nodules. This finding was in marked contrast to the virtual absence of lymphocytes surrounding similar lesions before immunotherapy. After immunotherapy, the contralateral inguinal lymph nodes had several subcapsular areas of pigmentation characterized by melaninladen histiocytes but no tumor cells.