Decreased vascular sensitivity to histamine during aging

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Abstract
The sensitivity of thoracic aorta preparations to histamine decreased with age. The responsiveness to histamine was unchanged. Indomethacin (17 μM) did not affect the basal tone of preparations from either young or old guinea pigs nor did the drug alter aortic sensitivity or responsiveness to histamine. The data show that (a) changes in vascular sensitivity to histamine during aging are not due to prostaglandins and that (b) prostaglandins do not act locally to modulate vascular tissue response to histamine.