Bringing chemistry to life
- 28 July 2011
- journal article
- research article
- Published by Springer Nature in Nature Methods
- Vol. 8 (8) , 638-642
- https://doi.org/10.1038/nmeth.1657
Abstract
Bioorthogonal chemistry allows a wide variety of biomolecules to be specifically labeled and probed in living cells and whole organisms. Here we discuss the history of bioorthogonal reactions and some of the most interesting and important advances in the field.Keywords
This publication has 50 references indexed in Scilit:
- Metabolic Labeling of Fucosylated Glycans in Developing ZebrafishACS Chemical Biology, 2011
- Biocompatible Copper(I) Catalysts for in Vivo Imaging of GlycansJournal of the American Chemical Society, 2010
- RETRACTED: Imaging Activity-Dependent Regulation of Neurexin-Neuroligin Interactions Using trans-Synaptic Enzymatic BiotinylationCell, 2010
- A Metabolic Alkene Reporter for Spatiotemporally Controlled Imaging of Newly Synthesized Proteins in Mammalian CellsACS Chemical Biology, 2010
- Rapid Cu-Free Click Chemistry with Readily Synthesized BiarylazacyclooctynonesJournal of the American Chemical Society, 2010
- Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of FunctionalityAngewandte Chemie International Edition in English, 2009
- Tetrazine Ligation: Fast Bioconjugation Based on Inverse-Electron-Demand Diels−Alder ReactivityJournal of the American Chemical Society, 2008
- A Hydrophilic Azacyclooctyne for Cu-Free Click ChemistryOrganic Letters, 2008
- A FRET‐Based Fluorogenic Phosphine for Live‐Cell Imaging with the Staudinger LigationAngewandte Chemie International Edition in English, 2008
- Redirecting lipoic acid ligase for cell surface protein labeling with small-molecule probesNature Biotechnology, 2007