A case is reported of a 24 yr. old girl with advanced rheumatic heart disease involving all the valves, tremendous cardiac enlargement, and long-standing congestive heart failure. Over a period of 12 yrs. she had 627 injs. of salyrgan or mercupurin totalling 1250 ml. In addition to the above, and to huge quantities of maintenance diuretics, she had 59 abdominal paracenteses. In spite of such massive therapy, there was no evidence of renal damage, good diuresis occurred with each inj., and she was able to carry on light physical activities until a few days before death.