Interferon Stabilization and Enhancement by Rare Earth Salts

Publisher Website
Google Scholar
Abstract
The addition of salts of the rare earth elements (lanthanides) enhances by a factor of 2 or more the initial activity of human fibroblast, leukocyte and immune interferons as well as mouse fibroblastic neoplastic L-cell interferon. The salts of the lanthanides (0.01-0.002 M) preserve the activity of human fibroblast interferon not only after 4 days of heating at 37.degree. C but also after exposure to severe shearing forces; human leukocyte interferon was stabilized to a lesser degree, albeit significantly. [These findings may have relevance to the preparation and purification of interferon for clinical use.].