Urinary crystalloid excretion in patients with inflammatory bowel disease

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Abstract
Because of the potential relationship of increased urinary crystalloid excretion and concentration to stone formation, urinary calcium and uric acid excretion patterns were studied prospectively in 65 patients with inflammatory bowel disease and compared with excretion patterns in patients with functional bowel disease (controls) receiving similar dietary prescriptions. Mean 24-hr urinary calcium excretion was higher in both ulcerative colitis (212 mg, p 700 mg. The mean urinary uric acid concentration was significantly higher in ulcerative colitis (538 μg/ml, p pH was lower (5·5, p <0·01) in ulcerative colitis than in the other groups. These results indicate increased excretion and higher concentration of calcium and uric acid in some patients with inflammatory bowel disease on the usual treatment programmes. Only very long-term prospective studies of such patients can help to document the true contribution of increased crystalloid concentration and excretion to kidney stone formation in inflammatory bowel disease patients.