Intrauterine Detection of Cystic Fibrosis
- 1 November 1980
- journal article
- research article
- Published by American Academy of Pediatrics (AAP) in Pediatrics
- Vol. 66 (5) , 690-692
- https://doi.org/10.1542/peds.66.5.690
Abstract
Human pregnancies [13] of obligate heterozygotes of cystic fibrosis were prospectively monitored, utilizing quantitative and qualitative measurements of methylumbelliferylguanidinobenzoate (MUGB) reactive proteases in amniotic fluid. In each case, the diagnosis was accurately ascertained in midtrimester and confirmed after delivery. The measurement of MUGB reactivity in midtrimester amniotic fluid by 3 different procedures, quantitative analysis, polyacrylamide isoelectric focusing and column filtration, appears to provide a practical and reliable approach for the intrauterine detection of cystic fibrosis.This publication has 0 references indexed in Scilit: