Drug-carrier property of albumin microspheres in chemotherapy. I. Tissue distribution of microsphere-entrapped 5-fluorouracil in mice.

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Abstract
After intravenous injection in mice, 5-fluorouracil-6-3H entrapped in albumin microspheres localized mainly in the liver, and the disappearance rate of radioactivity in microspheres from the tissue was very slow in comparison with that of free drug. Such preferential localization and sustained release of entrapped drugs suggested that albumin microspheres are useful as drug-carrier in chemotherapy.