Hypophysectomy mitigates skeletal muscle fiber damage in hamster dystrophy

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Abstract
Ablation of the pituitary gland by a rediofrequency lesion markedly retarded the musculoskeletal growth of young dystrophic hamsters. The prevalence of centronucleared muscle fibers, which is a reliable cumulative index of the microscopic patholgical expression of dystrophy, was drastically reduced in quadriceps muscles of 35‐ and 45‐day‐old hypophysectomized dystrophic hamsters, campared with sham‐operated controls. Mitigation of skeletal muscle fiber damage by musculoskeletal growth retardation may also occur in human dystrophy.