EFFECT OF METHOHEXITONE, DIAZEPAM AND SODIUM 4-HYDROXYBUTYRATE ON SHORT-TERM MEMORY
Open Access
- 1 February 1971
- journal article
- research article
- Published by Elsevier in British Journal of Anaesthesia
- Vol. 43 (2) , 113-116
- https://doi.org/10.1093/bja/43.2.113
Abstract
Short-term memory following the intravenous injection of methohexitone (0.15 mg/kg), diazepam (0.05 mg/kg) and sodium 4-hydroxybutyrate (10 mg/kg) has been examined by means of a visually presented digit retention test with intervals of 4 and 20 seconds before recall. No significant change was found with the 4-second interval; statistically significant impairment was found with the 20-second interval. It is postulated that the effect of these drugs is to accelerate decay of the memory trace, thus impairing its consolidation and producing anterograde amnesia. A versatile computerized test of short-term memory is described.Keywords
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