Oxyphil cells in thyroid disease: a uniform change?

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Abstract
Neoplastic and non-neoplastic oxyphil cells in thyroid disorders were investigated for enzyme and synthetic activity, ultrastructural features, and immune complex deposition. A reduced but definite content of thyroglobulin and similar enzyme profiles and ultrastructural features in all types of oxyphil change were found. Immune complex deposition was seen in Graves'' disease and Hashimoto''s thyroiditis but not in oxyphil neoplasms or colloid goitre with focal oxyphil change. The findings suggest that oxyphil cells do represent a uniform change. Immunonological damage with immune complex deposition might be the cause of oxyphil change in only some conditions.