Chronic Interstitial Pancreatitis

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Abstract
DURING the past century much investigative effort has been directed to the cause of 3 pancreatic inflammatory disease. Most of these studies have dealt with factors which initiate acute pancreatitis, and the chronic form of the disease has been relatively neglected. A number of methods have been developed which produce changes in the pancreas of experimental animals similar to those observed in human chronic interstitial pancreatitis. In most instances some form of exocrine obstruction has been employed to simulate duct obstruction, a factor considered important in the pathogenesis of pancreatic inflammation in man. Acute complete duct obstruction results in mild pancreatic edema from which most experimental animals recover quickly. There is no evidence that this simple maneuver alone will cause a progressive inflammatory reaction capable of initiating the cicatrical changes which characterize well developed chronic pancreatitis. Rather, the pancreas gradually undergoes atrophy, and within one month there is little evidence of

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