HEMODILUTION, OXYGEN-CONSUMPTION, AND RECOVERY FROM SURGICAL SHOCK - A STUDY ON THE EFFICACY OF DIFFERENT PLASMA SUBSTITUTES

  • 1 January 1981
    • journal article
    • research article
    • Vol. 13, 44-47
Abstract
The abilities (i.e., relative effectiveness). to several plasma substitutes to reverse a standardized intestinal ischemic shock in dogs and rats were compared. The colloids were given as 3.5% solutions in a dose of 1.5 g/kg = 43 ml/kg for dogs and and 2 g/kg = 57 ml/kg for rats. Ringer''s solution was given in a 3 times larger volume. Colloids of 3.5 6 and 10% concentrations and Ringer''s acetate were also given in increasing volumes for a test of the dose, concentrationand volume relationships. Ringer''s solution was effective during rapid infusion and for about 30 min after the infusion. Gelatin and ACD[acid-citrate-dextrose]-plasma was of corresponding effectiveness for 2 h. Albumin and dextran solutions maintained plasma volume and oxygen consumption for at least 4 h after the infusion. Colloids were more effective than Ringer''s solution at corresponding volumes, and even when 3 times larger volumes of the latter was given. Colloids of 3.5 and 6% were more effective than a 10% colloid solution. These effects were related to the MW distribution for colloids, the plasma volume expansion duration and their red blood cell aggregation properties. As single infusions, albumin, dextran 40 and dextran 70 are superior to ACD plasma, gelatin and Ringer''s acetate in restoring hemodynamic anfd metabolic functions and in improving survival rate.

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