One of the Antigenic Determinants of Paired Helical Filaments Is Related to Tau Protein1
- 1 April 1986
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Biochemistry
- Vol. 99 (5) , 1541-1544
- https://doi.org/10.1093/oxfordjournals.jbchem.a135625
Abstract
Paired helical filaments (PHF) are unusual neuronal fibers which accumulate progressively in the brain in Alzheimer's disease (AD). The insolubility of PHF in various kinds of solvents enabled us to obtain highly purified PHF, but prevented the application of conventional analytical methods to identify their components. Here we report that antibodies against purified PHF recognize tau protein, a brainspecific microtubule-associated protein, suggesting that a portion of PHF is tau protein.This publication has 6 references indexed in Scilit:
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