Studies on Copper Metabolism. XXV. Relationship Between Serum and Liver Copper.

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Abstract
Dietary restriction of Cu in adult Sprague-Dawley rats was followed by prompt decrease in serum Cu and slower, less extensive decrease in liver Cu. Feeding of diets high in Cu was followed by increase in concentration of Cu in both serum and liver. The increase occurred more rapidly in serum than in liver during the first 20 days, but thereafter the rate of increase was greater in liver than in serum. It is concluded that concentration of Cu in serum and liver is markedly influenced by dietary intake of Cu, that there is a close correlation between serum and liver Cu concentrations, and that there is both a "labile" and a "stable" liver Cu fraction.