CIRCADIAN VARIATIONS IN BLOOD LEVEL AND IN EFFECTS OF ETHANOL IN HEALTHY ADULT MAN (CHRONOPHARMACOLOGICAL STUDY)

  • 1 January 1975
    • journal article
    • research article
    • Vol. 70  (4) , 435-456
Abstract
Six healthy young men (22-26 yr) who had fasted for 12 h volunteered for this study (subject synchronization: diurnal activity from 0700 to midnight and nocturnal rest). A set dose of ethanol (0.67 g/kg) was ingested at the fixed (and random) hours of 0700, 1100, 1900 and 2300, with 1 wk between tests. A set of physiological variables, psychological tests (self-rating of mood, of physical vigor and of ebriety, tempo, random number addition test), physical variables (heart rate, systolic and diastolic blood pressure, peak expiratory flow, oral temperature and grip strength), blood variables (plasma ethanol, cortisol, lactic acid, pyruvic acid, glucose and erythrocyte K+) and urinary variables (volume, epinephrine, norepinephrine and 5-HIAA [5-hydroxyindoleacetic acid]) were documented at least at 4 h intervals and set times. The cosinor method was used for chronobiological statistical analyses. The parameters characterizing the ethanol pharmacokinetics (chronopharmacokinetics) demonstrated a circadian rhythm e.g., the peak height of ethanolemia was greater when ethanol was ingested at 0700 than at other times. A circadian rhythm in biosystems susceptibility was demonstrated (chronesthesy) with a peak time not necessarily corresponding to that of ethanolemia or to that of other variables. The overall circadian changes in ethanol effect (chronergy) were viewed as a combination of ethanol chronesthesy and chronokinetics.

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