Different levels of induction ofRecAprotein inE. coli(PQ 10) after treatment with two related carcinogens
Open Access
- 1 January 1983
- journal article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 11 (15) , 5235-5242
- https://doi.org/10.1093/nar/11.15.5235
Abstract
By means of an immunoradiotnetric assay the Induction of protein RecA in E. coli PQ 10 was measured after treatment by two related carcinogens. On an adduct basis N-Acetoxy-N-2-acetylaminofluorene was shown to induce the protein RecA at a similar level as U.V. On the other hand, N-hydroxy-N-2-aminofluorene shows only a poor induction capacity of the RecA protein. The difference in the SOS inducing potential of the aminofluorene and acetylami-nofluorene adducts is discussed in relation to the major difference in the local conformational change the two adducts induce in DNA.Keywords
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