Cytosine Arabinoside Stability in Intravenous Admixtures with Sodium Bicarbonate and in Plastic Syringes

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Abstract
The increased use of high-dose cytarabine [cytosine arabinoside] in the treatment of neoplasms prompted this study on the reconstituted stability of cytarabine in i.v. admixtures with sodium bicarbonate and in plastic syringes. The study of the effect of sodium bicarbonate was prompted by the frequent use of this agent, in patients being treated with cytarabine, as a means of achieving systemic alkalinization to manage hyperuricemia. The stability of reconstituted cytarabine in plastic syringes was measured to determine whether cytosine arabinoside could be reconstituted and stored prior to use. Sodium bicarbonate 50 meq/l in the i.v. solution containing cytarabine has no effect on the chemical stability of cytarabine for at least 1 wk at room temperature or in the refrigerator. Consequently, sodium bicarbonate and cytarabine can be coadministered in 1 i.v. solution. The reconstituted stability of cytarabine at 20 mg/ml and 50 mg/ml is not affected by storage in plastic syringes.

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