EXPRESSION OF A MYELOID MARKER ON TDT-POSITIVE ACUTE LYMPHOCYTIC LEUKEMIC-CELLS - EVIDENCE BY DOUBLE-FLUORESCENCE STAINING

  • 1 January 1982
    • journal article
    • research article
    • Vol. 60  (6) , 1392-1396
Abstract
The expression of a myeloid-specific antigen was detected on TdT[terminal deoxynucleotidyl transterase]-positive blast cell populations in 2 cases of childhood acute lymphocytic leukemia. Double-fluorescence staining by using the monoclonal antibody, VIM-D5, which is specific for cells of myeloid origin, in combination with TdT antiserum revealed that a distinct portion of the blast cells carried both markers. This is the 1st direct demonstration of this specific biphenotype in leukemic cells. It was interpreted as the abnormal expression of a myeloid antigen on lymphoid blast cells.