Chromatographic determination of promethazine hydrochloride in aqueous solution

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Abstract
Thin-layer and gas-liquid chromatographic techniques that are suitable for the determination of promethazine hydrochloride in aqueous solutions containing breakdown products are described. In both assay processes the degraded drug solutions are directly applied to the chromatograph without pre-extraction. The validity of the assays was confirmed in a kinetic study, which showed that the first-order rate constants obtained for the thermal or photolytic degradation of promethazine hydrochloride were not significantly different.