The Effect of Cycloheximide on Bile Flow in Rats

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Abstract
Cycloheximide (2 mg/kg i.p.) was shown to cause a significant reduction in bile flow in rats, when total bile drainage to the exterior was continuous over a period of 14 hr; the reduction was statistically significant after 8 hr. Biliary bilirubin excretion was significantly reduced (after 5 hr). However, when an intact enterohepatic circulation was maintained up to the beginning of a 1-hr collection period, no decrease in bile flow was recorded 4, 8, or 16 hr following cycloheximide. Reductions in bilirubin and bile acids were noted as being slight. Biliary bilirubin Tm was unaffected 1-24 hr after a single dose of cycloheximide. It is concluded that the cycloheximide affects the bile salt-independent component of bile flow in rats with continuous exteriorized total bile drainage.