On the Mode of Action of Silver Sulfadiazine

1 January 1972

journal article
Published by S. Karger AG in Pathobiology

Vol. 38 (4) , 296-308
https://doi.org/10.1159/000162423

Abstract

Silver sulfadiazine (CF-100) binds to deoxyribonucleic acid (DNA) but not to ribonucleic acid (RNA). DNA degradation is not observed. Nucleic acid and protein synthesis are not inhibited by silver sulfadiazine in cell-free systems. Conformational changes in the DNA are observed as evidenced by altered thermal transition, suggesting that silver sulfadiazine is inhibiting DNA replication.

Keywords

PROTEIN
THERMAL
MODE OF ACTION
CONFORMATIONAL CHANGES
SILVER SULFADIAZINE
DEOXYRIBONUCLEIC

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