Structural alerts to genotoxicity: the interaction of human and artificial intelligence
- 1 January 1990
- journal article
- research article
- Published by Oxford University Press (OUP) in Mutagenesis
- Vol. 5 (4) , 333-362
- https://doi.org/10.1093/mutage/5.4.333
Abstract
The assignments of ''structural alerts'' by Ashby and associates as predictors of genotoxic carcinogenicity were used as the entries for CASE, an artificial intelligence-based structure-activity relation method. CASE, using this human intelligence-based information, was able to derive structural determinants that duplicate the informational content of the structural alerts (sensitivity, 0.974; specificity, 0.948). The CASE-predicted alerts performed as well as the results of the Salmonella mutagenicity assay or the direct application of structural alerts in predicting carcinogens.This publication has 5 references indexed in Scilit:
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