PAIN MECHANISMS: Labeled Lines Versus Convergence in Central Processing
Top Cited Papers
- 1 March 2003
- journal article
- review article
- Published by Annual Reviews in Annual Review of Neuroscience
- Vol. 26 (1) , 1-30
- https://doi.org/10.1146/annurev.neuro.26.041002.131022
Abstract
▪ Abstract The issue of whether pain is represented by specific neural elements or by patterned activity within a convergent somatosensory subsystem has been debated for over a century. The gate control theory introduced in 1965 denied central specificity, and since then most authors have endorsed convergent wide-dynamic-range neurons. Recent functional and anatomical findings provide compelling support for a new perspective that views pain in humans as a homeostatic emotion that integrates both specific labeled lines and convergent somatic activity.Keywords
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