Production of vancomycin aglycone conjugated to a peptide carrier domain derived from a biosynthetic non-ribosomal peptide synthetase
- 2 October 2003
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 21,p. 2718-2719
- https://doi.org/10.1039/b308247d
Abstract
A method for attaching the vancomycin aglycone to a peptide carrier domain (PCD) is reported which involves reacting the apo-PCD produced in Escherichia coli with vancomycin aglycone-coenzyme A thioester, catalyzed by the phosphopantetheinyl transferase Sfp from Bacillus subtilis.Keywords
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