Anticholinergic (Banthine) Influences on Normal and Neurogenic Bladder Function

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Abstract
A study on the influence of Banthine (beta-diethylaminoethyl xanthene-9-carboxylate methobromide) on vesicular function was carried out on 4 normal subjects and 14 patients with neurogenic bladder dysfunction. A Lewis continuous recording cysto-meter was used to record the changes in intravesical pressure before and after admn. of Banthine. Banthine, an anticholingeric agent, exerts a profound depressant effect on the detrusor muscle in both normal and neurogenic bladders by producing a partial block of the parasympathetic innervation of the bladder. Control of urinary frequency and incontinence was obtained with banthine therapy in the uninhibited and reflex neurogenic groups of bladder dysfunction.