THE LIPID AND WATER CONTENT OF CARCASS, SKELETAL MUSCLE, AND TESTICLE IN THE HOST COMPONENT OF THE ALBINO RAT – WALKER CARCINOMA 256 DUAL ORGANISM AT PROGRESSIVE STAGES OF TUMOR GROWTH

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Abstract
The objective of this investigation was to find at what stage in the growth of Walker carcinoma 256 the shifts in water and lipid levels of host carcass, skeletal muscle, and''testicle, noted at or near death of the dual organism, appear. Lipid and water estimations were made on these tissues, at intervals of 1, 2, and 3 weeks of tumor growth, in 35 tumor-bearing and 34 littermate control albino rats. In host carcass, the decline in concn. /100 g. dry wt., of total lipid, neutral fat, and total fatty acids appeared after 2 weeks of tumor growth, while at or about the same time a rise occurred in the levels of water, total cholesterol, free cholesterol, and phospholipid. In hind limb skeletal muscle of the host, the levels of total lipid, neutral fat, and total fatty acids were lowered, while those of water were elevated, after 2 and 3 weeks of tumor growth. In host testicle, the levels of water and lipids were essentially similar to those of the controls. The rise in concn. of water, phospholipid, total cholesterol, and free cholesterol of the host varied, in general, with increase in the T/RC coefficient. Max. low levels of host total lipid, neutral fat, and total fatty acids were reached at T/RC coefficient (wet wt. of tumor divided by wet wt. of residual carcass multiplied by 100) values of 20 to 30. Maintenance of total body wt. was due mainly to accumulation of water in both components. The host component lost dry wt., total lipid, neutral fat, and total fatty acids more rapidly than these accumulated in the tumor in total amt. The smaller loss of total amts. of water, phospholipid, total cholesterol, and free cholesterol in the host was offset by an approx. equal accumulation of these substances in the tumor.

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