BLOOD-FLOW THROUGH EDEMATOUS EXTREMITIES

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Abstract
The O and CO2 content of blood from the femoral veins of both hind legs of dogs was studied before and after the injection of saline solution into 1 leg (to simulate clinical edema) and the volume outflow from both femoral veins was measured after such injection. The O-content was higher and the CO2 content lower in blood from the femoral vein of the "edematous" leg. The volume outflow from the femoral vein of the "edematous" leg was 50-400% higher than from the normal leg. It is postulated that the increased flow results from resistance by edema to passage of O into the tissues; that the effect of this, in addition to (and in spite of) increased blood-flow, is tissue anoxemia. No definite statements can be made as to the exact location of the augmented flow.

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