Regulation of acetylcholine receptor transcript expression during development in Xenopus laevis
Open Access
- 1 February 1988
- journal article
- research article
- Published by Rockefeller University Press in The Journal of cell biology
- Vol. 106 (2) , 469-478
- https://doi.org/10.1083/jcb.106.2.469
Abstract
Yeast cell surface growth is accomplished by constitutive secretion and plasma membrane assembly, culminating in the fusion of vesicles with the bud membrane. Coordination of secretion and membrane assembly has been investigated by examining the biogenesis of plasma membrane ATPase (PM ATPase) in secretion-defective (sec) strains of Saccharomyces cerevisiae. PM ATPase is synthesized as a approximately 106-kD polypeptide that is not detectably modified by asparagine-linked glycosylation or proteolysis during transit to the plasma membrane. Export of the PM ATPase requires the secretory pathway. In sec1, a mutant defective in the last step of secretion, large amounts of Golgi-derived vesicles are accumulated. Biochemical characterization of this organelle has demonstrated that PM ATPase and the secretory enzyme, acid phosphatase, are transported in a single vesicle species.This publication has 50 references indexed in Scilit:
- Molecular distinction between fetal and adult forms of muscle acetylcholine receptorNature, 1986
- Denervation supersensitivity in skeletal muscle: analysis with a cloned cDNA probe.The Journal of cell biology, 1984
- Structural homology of Torpedo californica acetylcholine receptor subunitsNature, 1983
- A major developmental transition in early xenopus embryos: I. characterization and timing of cellular changes at the midblastula stageCell, 1982
- Development of the myotomal neuromuscular junction in Xenopus laevis: An electrophysiological and fine-structural studyDevelopmental Biology, 1977
- Electrical stimulation of denervated muscles reduces incorporation of methionine into the ACh receptorNature, 1977
- Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase IJournal of Molecular Biology, 1977
- Screening λgt Recombinant Clones by Hybridization to Single Plaques in SituScience, 1977
- Onset of acetylcholine sensitivity and endplate activity in developing myotome muscles of XenopusNature, 1976
- OBSERVATIONS ON THE TERMINAL INNERVATION OF SEGMENTAL MUSCLE FIBRES IN AMPHIBIACells Tissues Organs, 1960