Epithelial and Fibroblastic Proliferation in Bovine Cutaneous Papillomatosis

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Abstract
The pathogenesis of the experimental bovine papilloma was investigated by the serial biopsy technique on lesions produced by epidermal scarification or intradermal injection using two strains of BPV. The purpose was to determine the time and sequence of stimulation of the epithelial cells and connective tissue. Following a morphological dormant phase, the first reaction was a fibroblastic proliferation. In papillomas developing from epidermal scarification, this was not marked and was followed by epidermal hyperplasia which progressed to the mature papilloma Fibroplasia in lesions produced by intrademal injection was always greater. Eight to ten % of the developing fibromas had a whorled histologic pattern. The percentage of sites inoculated showing fibroblastic change, although subtle, was high while the percentage going on to epithelial change was often much less, especially when inoculated by the intradermal route. The Feulgen technique did not reveal intranuclear or cytoplasmic bodies of any kind.

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