Chromosome assignment of four RAS-related RAB genes
- 1 February 1991
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 86 (4) , 350-354
- https://doi.org/10.1007/bf00201831
Abstract
The human RAB genes share structural and biochemical properties with the RAS gene superfamily. The encoded RAB proteins show 38 to 75% amino acid identity with the yeast YPT1 and SEC4 gene products. We used four human RAB-cDNAs, RAB3B, RAB4, RAB5 and RAB6, to map the corresponding genes on human chromosomes. These genes were assigned to 1p32-p31, 1q42-q43, 3p24-p22 and 2q14-q21, respectively, by in situ hybridization.Keywords
This publication has 21 references indexed in Scilit:
- Chromosome localization of human ARH genes, a ras-related gene familyGenomics, 1990
- Chromosome mapping of the human RAS-related RAP1A, RAP1B, and RAP2 genes to chromosomes 1p12→p13, 12q14, and 13q34, respectivelyCytogenetic and Genome Research, 1990
- Chromosome mapping of the human ras-related rab3A gene to 19p13.2Genomics, 1989
- Report of the committee on structural chromosome changes in neoplasiaCytogenetic and Genome Research, 1989
- Report of the committee on the genetic constitution of chromosomes 12 and 13Cytogenetic and Genome Research, 1989
- Report of the committee on the genetic constitution of chromosome 3Cytogenetic and Genome Research, 1989
- A GTP-binding protein required for secretion rapidly associates with secretory vesicles and the plasma membrane in yeastCell, 1988
- The yeast GTP-binding YPT1 protein and a mammalian counterpart are associated with the secretion machineryCell, 1988
- Regional localization of the LCA oncogene to human chromosome region 2q14→q21Cytogenetic and Genome Research, 1988
- Structure of the human and murine R-ras genes, novel genes closely related to ras proto-oncogenesCell, 1986