The role of Granzyme B in atheromatous diseasesThis paper is one of a selection of papers published in this Special Issue, entitled Young Investigators' Forum.
- 1 January 2007
- journal article
- review article
- Published by Canadian Science Publishing in Canadian Journal of Physiology and Pharmacology
- Vol. 85 (1) , 89-95
- https://doi.org/10.1139/y06-090
Abstract
The mechanism and role of apoptotic cell death in the pathogenesis of atheromatous diseases is an area of intense research. Atherosclerosis is an inflammatory disease and as such, immune-mediated cell killing plays an important role. Recent studies have suggested that Granzyme B and perforin play an important role in atherogenesis. The current manuscript reviews our current understanding pertaining to the role of Granzyme B in cardiac allograft vasculpathy and atherosclerosis.Keywords
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