OBSERVATIONS ON THE MECHANISM OF EXPERIMENTAL CEREBELLAR SEIZURES

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Abstract
The underlying mechanism of cerebellar seizures and the responses to electrical stimulation were studied by stimulating the cerebellum through implanted electrodes in a series of cats before and after operative procedures on different portions of the central nervous system. Cerebellar seizures could be induced in complete form after removal of 1 or both motor areas, or other large portions of cerebral cortex. Although the pathways concerned with the animal''s movements during the seizure are unknown, the seizures can occur in complete form after section of a cerebral peduncle, a pyramid, the dorsal roots to an extremity, both 8th nerves, or the upper 3 cervical nerves of both sides. Splitting the cerebellum or removal of half of it altered the pattern of the seizure and apparently confined it to the homolateral side of the body. Simultaneous stimulation of cerebral motor area and cerebellum resulted in effects from both regions apparently undiminished in extent. The pattern recognizable in the paired opposite movements of the phases of stimulus and rebound which commonly stimulation of the cerebellum is fundamental to the mechanism of the seizures and perhaps of normal cerebellar functioning.

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