Novel Meroterpenoids from Cystoseira mediterranea: Use of the Crown-Gall Bioassay as a Primary Screen for Lipophilic Antineoplastic Agents

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Abstract
Using a slight modification of the crown-gall potato disc bioassay, we were able to apply this test for two previously described antineoplastic lipophilic metabolites, didemnin B and mediterraneol A [1], and to use it as a guide for chromatographic separations of meroterpenoids from Cystoseira mediterranea. An active compound, mediterraneone [3], was isolated, and its structure was found to be a novel norsesquiterpenoid by chemical and spectral methods.

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