Selective hormonal control of myo-inositol biosynthesis in reproductive organs and liver of the male rat.

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Abstract
Myo-Inositol biosynthesis was examined in hypophysectomized and thyroidectomized male rats. After hypophysectomy, inositol-1-phosphate synthase [1L-myo-inositol-1-phosphate lyase (isomerizing), EC 5.5.1.4] in the reproductive organs and liver decreased markedly. At the same time, testicular acid phosphatase [orthophosphoric-monoester phosphohydrolase (acid optimum), EC 3.1.3.2] and .beta.-glucuronidase (.beta.-D-glucuronide glucuronosohydrolase, EC 3.2.1.31) increased. Thyroidectomy caused a similar decrease in inositol-1-phosphate synthase in the liver but not in the reproductve organs. FSH and luteinizing hormone restored the activity to at least normal levels in the testis, prostate and seminal vesicle but not in the liver of hypophysectomized animals. Triiodothyronine and thyroxine stimulated liver synthase 30-fold in hypophysectomized animals. Inositol-1-phosphate synthase in the reproductive organs apparently is under more or less direct control of the pituitary; in the liver, the control is mediated through the thyroid.