Generalized Membrane Defects in Cancer

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Abstract
THE neoplastic state is characterized by numerous and variable cellular derangements, but none of the many biochemical, immunologic, biologic and morphologic defects hitherto described are common to all tumors. Even tumors induced by a single agent in a single cell type can have a multiplicity of phenotypes, which tend to modulate in time. Pleomorphism and variation thus constitute a dominant aspect of neoplasia. The following discussion presents evidence that there may be a common feature underlying the diversity of neoplasia —namely, that alterations in one or more of their membrane systems is a regular feature of tumor cells.Plasma Membrane . . .