Histological Changes in the Rat Bone after Varying Doses of X rays with Particular Reference to Bone Tumour Production

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Abstract
The histological changes and the production of bone tumours have been studied in the hind limbs of some 257 rats after doses of X rays of 500 to 3,000 R. In some cases the 3,000 R was divided into three doses of 1,000 R or 6 doses of 500 R. The greatest number of tumors was found in the highest dosage groups, though with 500 R there was one bone tumor. The epiphyseal plate showed marked changes including transverse "splitting". Peritrabecular fibrosis only occurred in the 3,000 R group and there was no evidence to connect either this change or epiphyseal plate changes with the subsequent development of tumors. It is suggested that 2 different mechanisms may be operating in the single and fractionated dosage groups.