Theonellapeptolide IIIe, a New Cyclic Peptolide from the New Zealand Deep Water Sponge, Lamellomorpha strongylata
- 12 May 1998
- journal article
- review article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 61 (6) , 724-728
- https://doi.org/10.1021/np970417r
Abstract
The structure, stereochemistry, and conformation of theonellapeptolide IIIe (1), a new 36-membered ring cyclic peptolide from the New Zealand deep-water sponge Lamellomorpha strongylata, is described. The sequence of the cytotoxic peptolide was determined through a combination of NMR and MS−MS techniques and confirmed by X-ray crystal structure analysis, which, with chiral HPLC, established the absolute stereochemistry.Keywords
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