G Protein-Coupled Receptor Dimerization: Function and Ligand Pharmacology
Top Cited Papers
- 1 July 2004
- journal article
- review article
- Published by Elsevier in Molecular Pharmacology
- Vol. 66 (1) , 1-7
- https://doi.org/10.1124/mol.104.000497.
Abstract
It is now generally accepted that G protein-coupled receptors (GPCRs) can exist as dimers or as part of larger oligomeric complexes. Increasing evidence suggests that a dimer is the minimal functional structure, but considerable variation exists between reports of the effects of agonist ligands on quaternary structure. Many studies have intimated the existence of heterodimeric GPCR pairings. Key questions that remain to be addressed effectively include the prevalence and relevance of these in native tissues and the implications of heterodimerization for pharmacology and, potentially, for drug design.This publication has 41 references indexed in Scilit:
- GPCR dimerisationLife Sciences, 2003
- Is rhodopsin dimeric in native retinal rods?Nature, 2003
- Blockade of G Protein-Coupled Receptors and the Dopamine Transporter by a Transmembrane Domain Peptide: Novel Strategy for Functional Inhibition of Membrane Proteins in VivoThe Journal of Pharmacology and Experimental Therapeutics, 2003
- Ligand-independent CXCR2 DimerizationJournal of Biological Chemistry, 2003
- Dual Inhibition of β-Adrenergic and Angiotensin II Receptors by a Single AntagonistCirculation, 2003
- D2 Dopamine Receptor Homodimerization Is Mediated by Multiple Sites of Interaction, Including an Intermolecular Interaction Involving Transmembrane Domain 4Biochemistry, 2003
- Homodimerization of Neuropeptide Y Receptors Investigated by Fluorescence Resonance Energy Transfer in Living CellsJournal of Biological Chemistry, 2003
- Monitoring of Ligand-independent Dimerization and Ligand-induced Conformational Changes of Melatonin Receptors in Living Cells by Bioluminescence Resonance Energy TransferJournal of Biological Chemistry, 2002
- Oligomerization of G-protein-coupled Receptors Shown by Selective Co-immunoprecipitationJournal of Biological Chemistry, 2002
- Two Defective Heterozygous Luteinizing Hormone Receptors Can Rescue Hormone ActionJournal of Biological Chemistry, 2002