Highly regio- and stereo-selective synthesis of 1-(2-hydroxyaryl)glycerol derivatives under ultrasonic irradiation
- 1 January 1987
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 10,p. 794-796
- https://doi.org/10.1039/c39870000794
Abstract
Complementary diastereoselectivity in the C-arylation of (R)- and (S)-2,3-O-isopropylideneglyceraldehyde by using Mg2+-based (syn-addition) and Ti4+-based (anti-addition) phenolates allows the efficient preparation of all four possible stereoisomers of the title 1-C-substituted glycerols; the application of ultrasonic waves produces a marked synthetic advantage.Keywords
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